It takes effect from today.
All Aer Lingus and Emerald Airlines regional flights serving Manchester now depart and land at Terminal 2.
Aer Lingus joins several airlines which have relocated to the terminal.
T2 is the centerpiece of the airport’s £1.3billion transformation and becomes the primary terminal at the airport.
Work is still continuing which will see the closure of Terminal 1 while Terminal 3 will be expanded.
Terminal 2 is getting a host of new retail outlets and dining options including a food hall.